Here you can find vast information about the CBD and its effect on our health in so many aspects.

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1. Cell culture study on the cytotoxic effects of “Cureit”- a novel bioavailable curcumin-anti cancer effects.
2. Cell Culture Study on the Effect of Bio-Available Curcumin – “Cureit” on Elastase Inhibition Activity.
3. A Pilot Cross-Over Study to Assess the Human Bio-Availability of “Cureit” A Bio-Available Curcumin in Complete Natural Matrix.
4. CELL CULTURE STUDY ON THE EFFECTS OF “CUREIT”-A NOVEL BIOAVAILABLE CURCUMIN ON HYALURONIDASE INHIBITION – ANTI AGING EFFECTS.
5. Anti Oxidant Potential of “Cureit”- A Novel Bio-Available Curcumin Formulation.
6. Cell Culture Study On The Effects Of “Cureit”- A Novel Bio-Available Curcumin On Boosting Phagocyte Mediated Immunity.
7. Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open-label Parallel-arm Study.
8. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review.
9. A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.
10. Development of Validated Methods and Quantification of Curcuminoids and Curcumin Metabolites and Their Pharmacokinetic Study of Oral Administration of Complete Natural Turmeric Formulation (Cureit) in Human Plasma via UPLC/ESI-Q-TOF-MS Spectrometry.
11. Preparation of a novel bioavailable curcuminoid formulation (Cureit) using Polar-Nonpolar-Sandwich (PNS( technology and its characterization and application.

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What are the Advantages?

Aktin Technology combines the best aspects of two pharmaceutical forms, capsules and liposomes. We created this combination to provide you with the benefits of both.

Benefits include:

• Preservative-free
• Easy-to-swallow capsules
• Increased absorption of active ingredients
• On-the-go products
• Shelf-stable
• Easy storage
• No sacrifice in bioavailability

How do we do this?

1. Smarter Packaging:
   Liposomes are tiny balls made of lipids and water. They are made of the same ingredients as your cells are and can unite with them. When this happens, the load of the active ingredient is released into the intestinal cells and dispatched to all the cells throughout your body.
2. Smarter Delivery Method:
   We use a smarter delivery method called targeted delivery.
   This means we’ve designed the carriers that travel to where they need to.
   Instead of just generally releasing the active ingredient in the stomach hoping the active ingredient will find its mark.
   As a result, much more ingredient can reach the most crucial area – your intestine, where absorption takes place.
3. How can AKTIN technology improve your well-being?
   Every product carrying an AKTIN logo is designed with your health in mind.
   Our primary goal is to provide you with the most effective supplements, so you receive maximum benefits and feel your best! Some actives might be potent, but a lot of them may be very poorly absorbed.
   Improve your well-being, AKTIN technology enhances the absorption of these active ingredients.
   In the past liquid liposomal formulations or formulations with detergent-like ingredients were the only way to efficiently deliver actives to your body that was difficult to absorb.
   Now, studies have shown that AKTIN technology’s dry liposomes are better for absorption compared to ordinary capsulated counterparts.
   Since AKTIN ’s products have been shown to be better absorbed, less active ingredient is wasted because of the efficient delivery system.

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For over 5,000 years the Turmeric root has been used as an important spice for the Asian cuisines.
It is consumed daily by more than a third of the world’s population!!!
However, apart from its culinary use, Turmeric has a long tradition of worldwide medical use in Indian medicine (Ayurveda), Chinese medicine and Western herbal medicine.
In recent years, the main active ingredient in the root called Curcumin or Curcuminoids is associated with the medicinal properties of the plant.
The Curcumin is also the source of the strong orange-yellow pigments that the root is famous for.

Curcumin and Bioavailability

What Is Bioavailability?

Biological availability refers to the measure of an active substance in the bloodstream and its ability to reach target cells.
When a nutrient is introduced intravenously by infusion or injection, its bioavailability will be particularly high (The maximum bioavailability is 100%), but when those components enter the body in other ways, such as swallowing, their bioavailability decreases significantly due to absorption and disintegration problems in the digestive system.
When a nutrient is highly bioavailable, it can be digested and absorbed at a high percentage of the time and in a dependable way.
When an active substance bioavailability is poor, digestion and absorption would probably be less effective and much less predictable.
Supplements that are absorbed in the intestines are ultimately available for biological activity in cells and tissues.

What About Curcumin?

Curcumin is the main active ingredient in Turmeric root.
Curcumin is considered to be the most studied natural component worldwide, which has been covered by thousands of publications and scientific studies.
However, over the years the main obstacle in the curcumin has been its low bioavailability.
The potential for its beneficial effects decreases significantly since the digestive system is a liquid acidic environment, and Curcumin which is an oil-soluble element does not effectively process through the digestive system.
In order for the Curcumin to access the target cells in the intestinal tract, there must be a fat-soluble agent to ensure absorption.

Introducing PNS Technology

PNS (Polar Non-polar sandwich) is an innovative, unique, technological breakthrough.
The PNS technology utilizes the complete natural complex extracted from the Turmeric root in order to enhance the Curcumin absorption.
The patent-pending technology, PNS stands for Polar Non-polar Sandwiching Technology (Patent application number – E-1/11319/2015-CHE).
This advanced and breakthrough development is aimed to increase the biological availability of curcuminoids, using the natural properties and composition of the Turmeric roots. It is designed to preserve the Curcuminoids properties and increase the stability of the active substance by controlling the release of the active substance.
As a result, the amount of active ingredient increases upon its arrival at the target cells, leading to high-efficiency and high Bioavailability of curcuminoids metabolizing in the intestinal tissue and into the bloodstream.

How PNS Technology Works?

NON-POLAR or POLAR
Polarity influences the ability of materials to merge.
Materials tend to blend easily with other materials with the same polarity level.
When it comes to molecules, different criteria determine whether a molecule is polar or non-polar, such as its electrical charge or the symmetry of the molecular structure.
When a same couple of polar or non-polar molecules encounters, they tend to merge, whereas when a polar molecule meets a non-polar molecule, they reject each other.
In other words, polarity is the considerable key factor when absorption is demanded.

The best example of polarity is the reaction between water and oil:

While the water electrical charge is in a polar structure, oil carries a non-polar electric charge and structure, so water and oil reject each other when mixed.
On the other hand, when mixing water with another polar structured substance such as apple juice, the water, and the juice merge and form a unified compound.
Mixing non-polar materials such as oil and gasoline, the materials assimilate and merge completely.
Curcuminoids absorption presents a similar problem.
The intestinal lining is made of a polar structure, while the Curcuminoids carry a non-polar structure, so the intestinal tissue rejects the active substance and is not absorbed into the bloodstream.
In order for the Curcuminoids to penetrate the intestines efficiently, the structure carrying a polar charge needs to be identical to the digestive system.

PNS bio-delivery system

Through an advanced process, the natural composition of Turmeric is integrated into Polar Non-polar Sandwiching (PNS)

The process includes isolating Curcumin and “sandwiching” it between the Polar (carbohydrates, dietary fiber and proteins from the Turmeric) & the Non-polar (Turmeric oil).

Using PNS technology, Curcuminoids are a non-polar charge coated with layers of proteins and water-soluble carbohydrates, which are also derived from the full Turmeric root and form a polar structure that is able to penetrate the intestinal wall and deliver the Curcumin active substance in maximum absorbency.

PNS Technology uses all the components of Turmeric and structures it in a way that Curcumin can be absorbed directly into target cells, without disintegration of the digestive tract, which increases bioavailability.

A study conducted by the Asian Journal of Pharmaceutical Technology and Innovation tested 12 healthy men aged 18-45.

The objective of the study was to compare blood plasma levels between two kinds of Curcumin extract.
The first contained Curcumin by PNS technology and the other contained a highly concentrated 95% Curcumin extract.
The study results revealed that the Curcumin blood plasma level at the group consuming the PNS extract was 10 times!!! higher compared to the group consuming the 95% Curcumin extract.

study reference:

Cell culture study on the cytotoxic effects of “Cureit”- a novel bioavailable curcumin-anti cancer effect.

Cell Culture Study on the Effect of Bio-Available Curcumin – “Cureit” on Elastase Inhibition Activity.

A Pilot Cross-Over Study to Assess the Human Bio-Availability of “Cureit” A Bio-Available Curcumin in Complete Natural Matrix.

CELL CULTURE STUDY ON THE EFFECTS OF “CUREIT”- A NOVEL BIOAVAILABLE CURCUMIN ON HYALURONIDASE INHIBITION – ANTI AGING EFFECTS.

Anti Oxidant Potential of “Cureit”- A Novel Bio-Available Curcumin Formulation.

Cell Culture Study On The Effects Of “Cureit”- A Novel Bio-Available Curcumin On Boosting Phagocyte Mediated Immunity.

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What is Cannabis?

The cannabis plant has apparently accompanied humanity from its very beginning, either as a medical based use for therapeutic purposes in many cultures for centuries or as an industrial plant which the main use is manufacturing ropes and fabric from the plant’s fiber.
Cannabis is made up of more than 120 components, which are known as cannabinoids.
Data about the effects of each cannabinoid is still mostly unknown, but they’re a good understanding and research about two of the cannabinoids, known as cannabidiol (CBD) and tetrahydrocannabinol (THC).

What is CBD?

Cannabidiol (CBD) is a Phyto-cannabinoid found in Cannabis is a naturally occurring compound found in the resinous flower of cannabis.
It does not exhibit the psychoactive effect as produced by THC.
CBD is an intensively researched cannabinoid and has a high medical potential.
CBD research suggests possible positive effects, the most intensive research has been conducted for areas such as:

• Antipsychotic and antidepressant effects
• Analgesic and anti-inflammatory effects
• Antidiabetic effects
• Anxiety-related disorders (Panic disorder, OCD, PTSD, GAD)
• Prevention of epileptic seizures in some types of epilepsy
• Anti-metastatic mechanism (inactivation of Id-1 and Id-3 genes, which allow the migration of cancer cells – metastasis)
• Inhibition and prevention of tumor growth
• Promotion of tumor cells apoptosis

What about THC?

THC cannabinoid has useful health benefits and may help with conditions
such as pain, muscle spasticity, insomnia, low appetite, nausea, etc.
Unfortunately, THC has a psychoactive effect.
In some individuals, the psychoactivity can cause some negative side effects, including anxiety, panic attacks, and general psychic discomfort.
However, this is the case majorly in individuals with a medical/family history of depression, anxiety, and other psychiatric disorders when THC is used individually.
Due to its properties and side effects profile, we believe, it should be used only under medical doctor supervision.

CBD Studies

There have been many studies on the effect of CBD on cancer cells.
One study describes the effect of CB on apoptosis (Programmed Cell Death).
The study conducted and published in 2015 suggested that:
“Over the past decade, researchers have refocused their efforts on the therapeutic potential of non-psychotropic cannabinoids in CS, particularly, CBD.
As presented in this review, the preclinical data strongly support the notion that non-psychoactive plant-derived CBs can act as direct inhibitors of tumor progression as well as enhance the activity of first-line therapy. ”

Research published in 2012 review the therapeutic potential of cannabidiol in psychiatric disorders:
“CBD is a safe compound with a wide range of
therapeutic applications, including the treatment of
psychiatric disorders.
These findings make this drug an attractive candidate for future clinical use.
Its therapeutic use, however, has some limiting factors.
In addition to its low and variable oral bioavailability in
humans, it causes bell-shaped dose-response
curves and, judging from the studies with laboratory
animals possess a narrow therapeutic dose range.”

As reported in the study despite the medical potential of cannabidiol (CBD), the main problem is bioavailability.

The liposomal solution for CBD

Liposomal formulations technology is a carrier system for nutrients to increase bioavailability.
The liposome is a natural lipids coating around the nutrients, and they diffused in the cell membrane a process which significantly improves bioavailability.
Neo-Cure conducted a study comparing the liposomal version of Cannabis and other commercially available oil solution of Cannabis sativa plant extract with a high amount of CBD.
The study examined CBD in the blood plasma density for 24-hours, following the oral intake of human volunteers comparing liposomal CBD formulation and oil-based formulation.
The conclusion shows the CBD blood plasma concentration is 270% higher than the traditional CBD oil solution.
The liposomal technology enhances the health effects of the CBD component.

Further studies on the health effects of CBD

Cancer and CBD studies
Autism
Asthma
GI cancer
Epilepsy
Inflammatory diseases
Pain treatment
Parkinson’s
Psoriasis
Cardiovascular

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How liposomal technology is used in supplements?
Liposomal technology is used to facilitate the liposome as a carrier of active ingredients in drugs or supplements, particularly for active ingredients with low absorption in the digestive system.
This unique patented technology makes sure the liposome is naturally diffused in the cell membrane and enhances the active ingredients absorption rate significantly, in any form, whether in a liquid product, in capsules or tablets.
The significant advantage of liposomal products is the natural lipids coating around the ingredients which increases the stability of the supplement, and prevents its breakdown in the acidic environment of the stomach, thus carrying it in a protected manner throughout the entire digestive system until it is properly absorbed in its destination.
In addition, because of the natural coating, high doses of the supplement (such as vitamin C when catching a cold) can be used without causing gastrointestinal irritation and other inconveniences.

Liposomes composition and mechanism formation:
Liposomes are made up of phospholipids – natural molecules with a unique structure that allows them to be both hydrophilic and lipophilic at the same time.
When phospholipids are injected into an aqueous environment, due to the unique combination of oil and water-soluble components, they instantly organize themselves into globular structures (fatty bubbles).
As mentioned before, the various potential use of liposomes is derived from the unique properties of the phospholipids which are molecules with hydrophilic (water-binding) and hydrophobic (water repellent).
When in contact with water, the phospholipids immediately crystallize into a globular structure called colloid.
The hydrophilic phospholipid head binds with the water molecules, while the hydrophobic phospholipid tail moves away from the liquid and to the bubble core’s center, thus creating the characteristic liposomal structure.
This unique structure of the liposomes allows capturing water-soluble components (such as vitamin C and vitamin B12) in their inner core, while the two-layer hydrophobic layer traps oil-soluble components (such as curcumin and coenzyme Q10).
Thanks to this exceptional ability, the liposomes have become a popular carrier in the pharmaceutical and dietary supplements industry.

The absorption of nutrients in the small intestine is occurring in cells named enterocytes, which are covered with microvilli absorption structures.

Liposomal Bioavailability:
The substantially increased amount of the active ingredients of liposomal drugs or dietary supplements in the blood-stream is the evidence for absorption improvement increased bioavailability of high-quality liposomal products.

For this reason, we conducted pharmacokinetic studies, which indicate the level of absorption and biological availability of different products:
From a scientific standpoint, the absorption rate of certain components consumed in swallowing decreases as the supplementation dose is higher. For instance, the common side effect of high vitamin C doses is osmotic diarrhea, caused by the accumulation of excessive fluids in the digestive system.
Therefore, the highest tolerable dose of ingestion of vitamin C is 3-4 grams. Surprisingly, studies in pharmacokinetics (a field that examines the movement and metabolism of a drug or supplement in the body after ingestion) show that supplementing vitamin C in dosages less than 100 mg per day sharply increases its blood concentration.
The range of 100 mg – 400 mg/day, gradually decreases the concentration of vitamin C in the blood-stream until the final measurement of a low concentration measuring 70-80 pmol / L, doses greater than 400 mg per day that result in only a slight increase of vitamin C concentrations in the blood-stream.
Using vitamins produced by liposomal technology enables the administration of high doses while improving vitamin absorption and increase the vitamin concentration in the blood-stream.
For instance, in two patients who took 36 mg of liposomal vitamin C, the concentration in the blood of the vitamin increased to more than 500 pmol / L – a level that can usually be achieved only by intravenous administration.

What are the indicators of a high-quality liposomal product?

• A stable liposomal composition – a combination of a natural molecule of phosphatidylcholine that ensures stable liposome production, and the use of artificial components such as PEG.
• Uniformly minimized particle – the size of the liposome is a critical factor in determining its half-life cycle (duration of survival).
• Liposomes smaller than 100 nm remain active for a longer time, so their potential as absorption enhancers is higher.
• Also, the immune system has increased difficulties in identifying and dissolving (in a process called opsonization) liposomes smaller than 100 nanometers, another fact that helps prolong their activity.
• NO genetic engineering– it is necessary to use high-quality phospholipids and phosphatidyl-choline from non-genetically engineered sources.
• Use of high-quality active ingredients ensures high-quality products hence most effective results.
• Products supported by stability studies and bioavailability studies.

Pharmacokinetic study results: Liposomal vitamin C

Results of the study graphically:

The blue curve describes the liposomal vitamin C level measured in the blood, while the red curve describes the level of non-liposomal vitamin C in the blood.
The study results indicate that the potential for liposomal vitamin C oral administration is an appropriate alternative to intravenous vitamin C treatment.

Liposomal Products Analysis
providing conclusive evidence for the product’s stability, EcoSupp conducted analyses on four products – two of which contain active water-soluble materials, and two other product containing active oil-soluble materials.
The analysis was carried out in an external laboratory using nanoscale laser scanning instruments: NanoSight LM20, which identifies the particles and follows their Brownian motion to determine their size.

test results:

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The unique process of binding the minerals to amino acids requires controlled production processes, strict manufacturing conditions and the most innovative manufacturing facilities in the field.
Each mineral has a unique manufacturing process adapted for it.
As a result, Albion has more than 100 registered patents on a wide range of products based on TRAACS binding technology that bind minerals to amino acids.
Albion has become the world’s leading manufacturer of minerals as nutritional supplements, thanks to the advanced patented technology which produces among the highest quality mineral products available.
The technology has succeeded in creating an organic molecule that the body can effectively assimilate and use to provide various biological and health benefits.
The formation criteria of these compounds must be subject to production restrictions:

• The weight of the molecule must be less than 800 Dalton (a unit of an atomic mass unit).
• The electrical charge of the molecule must be neutral.
• The molecule must stay stable to prevent a chemical reaction in the digestive system.
• The compound must be bioavailable

Albion TRAACS method meets all these criteria and provides mineral compounds and amino acids with significant advantages such as:

• High bioavailability (due to high absorption of active substances through the bowel barrier to the bloodstream).
• The compounds are easy to digest and do not cause side effects and irritate the digestive system.
• The compounds do not interact with other foods that prevent mineral absorption.
• The compounds are made from 100% essential nutrients to the body.

Studies comparing various mineral supplements have shown that glycine chelated based supplements are more bioavailable compared to other mineral supplements available.
For example, a clinical study comparing the bioavailability of magnesium bisglycinate supplementation with magnesium citrate supplement found that magnesium bisglycinate had higher bioavailability than magnesium citrate, plus, the supplement absorption was in different areas of the gastrointestinal tract.

Click here to read the study.

In a different study comparing the bioavailability of zinc bisglycinate with zinc gluconate also concludes that zinc bisglycinate (based on the binding amino acid & glycine) bioavailability is higher than zinc gluconate significantly.

In addition, various studies have shown that Albion’s amino-mineral compounds don’t cause side effects as other mineral compounds available.

Minerals such as iron and magnesium are known to cause problems and discomfort in the digestive tract, constipation or diarrhea, and even nausea, vomiting, increased acidity in the digestive system.

TRAACS method absorption level is clearly high but the commonly asked question is it safe?
Safety tests for the iron compound combined with the albino amino acids are confirmed safety for short and long term use.
The following studies covered that subject:

• The opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids, in Contact with Foods Related to Ferrous Bisglycinate as a source of Iron for Use in the Manufacturing of Foods and in Food Supplement.
• Toxicology and safety of Ferrochel and other iron amino acid chelates.

The TRAACS method most important challenge is the ability to provide significant health benefits for its users, which is the reason consumers choose to use supplements in the first place.
The TRAACS production method for amino acids & mineral based compounds may give additional physiological benefits for those who use the supplements, such as improving athletic performance as demonstrated in various studies.

TRAACS production method has created very high bioavailability, fast and easy digestion in the digestive system.

This technology enables the creation of products suitable for people suffering from absorption difficulties such as elders, people suffering from gastrointestinal diseases, or people who underwent gastrointestinal procedures such as surgery to remove parts of the intestines, and do not cause side effects such as gas, constipation, Abdominal pain.
For instance, a clinical study compared the biological availability of magnesium bisglycinate to magnesium oxide in patients with intestinal resection.
The study concludes that the absorption of magnesium bisglycinate was more efficient.

Albion’s mineral products are:

• Easy to digest and absorb effectively in the gastrointestinal tract.
• Soluble and stable in an acidic environment (such as in the stomach).
• Hypoallergenic, gluten-free, vegan, genetically modified, free of animal components (BSE free).
• Approved configurations from the European Food Safety Authority (EFSA).

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